Maternal nutrient restriction (MNR) in pregnant guinea pigs and the impact on fetal growth and brain development.
نویسندگان
چکیده
منابع مشابه
Effect of 30% nutrient restriction in the first half of gestation on maternal and fetal baboon serum amino acid concentrations.
Mechanisms linking maternal nutrient restriction (MNR) to intra-uterine growth restriction (IUGR) and programming of adult disease remain to be established. The impact of controlled MNR on maternal and fetal amino acid metabolism has not been studied in non-human primates. We hypothesised that MNR in pregnant baboons decreases fetal amino acid availability by mid-gestation. We determined matern...
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Intrauterine growth restriction increases the risk of perinatal complications and predisposes the infant to diabetes and cardiovascular disease in later life. Mechanisms by which maternal nutrient restriction (MNR) reduces fetal growth are poorly understood. We hypothesized that MNR decreases placental amino acid (AA) transporter activity, leading to reduced transplacental transfer of AAs. Preg...
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Purpose: Intrauterine growth restriction (IUGR) is defined as a fetus that is not maintaining its genetic growth potential in utero. This reduced growth is often caused by placental insufficiency resulting in decreased nutrient and oxygen supply to the fetus. To increase the likelihood of survival, fetal adaptations occur, which include brain sparing leading to asymmetric growth restriction, al...
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ورودعنوان ژورنال:
- International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
دوره 47 Pt A شماره
صفحات -
تاریخ انتشار 2015